Question for the #epidemiology crowd: setting politics aside, what impact, if any, does the origin of the #Covid19 pandemic have on the course of this disease?

For example, if this pandemic was caused by a lab-modified corona virus, would this have implications for this virus's evolutionary course?

For the purposes of predicting epidemiological outcomes, do "initial conditions" matter in this context?

If there are peer-reviewed papers I should read on this, a nose-point would be great.